Objective To study the function of angiogenesis and the relative factors: vascular endothelial growth factor ( VEGF) and basic fibroblast growth factor ( bFGF) in the course of gastric ulcer healing, and to explore the molecular mechanism in intractable gastric ulcer. 目的研究血管形成和血管形成相关因子碱性成纤维细胞生长因子(bFGF)、血管内皮生长因子(VEGF)在消化性溃疡发病中的作用,探讨难治性胃溃疡的血管分子学机制。
The Significance of VEGF and bFGF Expression and Mini-Blood-Vessel-Density Determination in Intractable Gastric Ulcer VEGF、bFGF表达和微血管密度检测在难治性胃溃疡中的意义
Methods 28 gastric tissues adjacent to and distant from intractable gastric ulcer during gastrectomy were collected for determination of submucosal capillary counting and VEGF and bFGF proteins by immunohistochemistry. 方法收集28例因难治性溃疡和并发穿孔等行胃大部切除的患者作为难治性溃疡组,取其溃疡周边和远处组织;
Conclusion Contrasted with the normal gastric tissue, the amount of capillaries and expression of VEGF/ bFGF decreased significantly, which is one important cause of the delayed healing of intractable gastric ulcer. Angiogenesis may be one of the important methods for treating the gastric ulcer. 结论与正常胃组织相比,溃疡病灶周边组织血管数量明显减少,VEGF、bFGF表达下降,这是难治性胃溃疡经久不愈的一个重要原因,血管形成应是防治溃疡的重要方法之一。
Treatment of chronic intractable skin ulcer of the aged 老年人慢性顽固性皮肤溃疡的治疗
The clinical study of needle-pricking therapy in refractory and intractable peptic ulcer 针挑疗法治疗难治性和顽固性消化性溃疡的临床研究